Evaluation of Anti-ulcer activity of Ethanolic Extract of Nymphaea Alba Linn Flower in experimental rats.
Ashish K. Paharia1*, A. Pandurangan 2
1.Department of Pharmaceutical Science, Shri Venkateshwara University, Gajraula (U.P.) India
2.M. M. College of Pharmacy, MM University Mullana (Ambala) Haryana, India
In the present study Anti ulcer activity of Ethanolic Extract of flower of Nymphaea alba Linn were investigated. The Anti ulcer activity of Ethanolic Extract of flower of Nymphaea alba were evaluated by Pylorus ligation & Ethanol induced ulcer model in experimental rats. In both models the common parameter determined was ulcer index. The Ethanolic Extract of Nymphaea alba (200 & 400 mg/kg) treat the Ulcer and produced significant inhibition of the gastric lesions induced by Pylorus ligation induced ulcer & Ethanol induced gastric ulcer. Preliminary Phytochemical analysis of Ethanolic Extract of Nymphaea alba revealed that the presence of various phytoconstituents Alkaloids, Carbohydrates (Polysaccharides), Glycosides, Steroids, Flavonoids and Tannin & Phenolic compound. The extract (200 mg/kg & 400 mg/kg) showed significant reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that Nymphaea alba Linn flower extract have potential Anti ulcer activity in the both models. These results may further suggest that Ethanolic extract was found to possess Antiulcerogenic as well as ulcer healing properties, which might be due to its Anti-secretary activity.
Keywords: Nymphaea alba Linn, Pylorus ligation, Ethanol induced ulcer model, ulcer index.