DOI: 10.21276/ajptr
Tue, 22 Jan 2019

Formulation Development and Evaluation of Immediate Release Tablet of Armodafinil by Drygranulation Method Using Superdisintegrants


Iswaryakarapareddy1*, Imrankhanpatan2, Nagarjuna Reddy3. K, Subhojit samanta1, C.M.Vaijayanthi1, Mrs. Ramya1

1. Department of Pharmaceutics, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore. India.

2. Department of Pharmaceutics, Sanjeevan College of Pharmacy, Dausa, Jaipur.

3. Department of Quality Assurance, Krupanidhi College of Pharmacy, Bangalore.



Armodafinil is very slightly soluble in water; hence the drug may be slowly or incompletely dissolved in the gastro intestinal tract. So the rate of dissolution and therefore its bioavailability is less. In the present study an attempt has been made to prepare immediate release tablets of Armodafinil by using different superdisintegrants (croscarmellose sodium, pregelatinized starch and Avicel pH 101 to increase the rate of drug release from dosage form or the dissolution rate and hence its bioavailability. The prepared granules and tablets were evaluated for their physiochemical properties and in-vitro dissolution study was conducted for the prepared tablets. The in-vitro dissolution studies shows the release in the following order of superdisintegrants is croscarmellose sodium> Pregelatinized starch> Avicel PH 101. It was concluded that the immediate release tablets with proper hardness, disintegration time and with increase rate of dissolution can be made using croscarmellose sodium as superdisintegrants (F9). The formulation F9 was selected as an optimized formulation for stability study and the in-vitro dissolution study showed that was no difference in percent of drug released between 1st month and 3rd month sample.

Keywords: Armodafinil, Immediate release tablets, Superdisintegrants, Magnesiumsterate

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