DOI: 10.21276/ajptr
Tue, 22 Jan 2019

UV Spectrophotometric Method for Simultaneous Determination of Tamsulosin and Finasteride in Combined Dosage Form


Mahesh Nasare, Satish. J*, Manikanta Kumar. A, M. Akiful Haque, V.V.L.N.Prasad, Prakash.V. Diwan

1.School of Pharmacy, Anurag Group of Institutions, Venkatapur (V), Ghatkesar (M), Rangareddy (D).



A simple, rapid and specific UV spectrophotometric method with good sensitivity was developed and validated for the simultaneous determination of tamsulosin and finasteride in bulk and pharmaceutical formulations. In methanol, the lambda max of finasteride and tamsulosin was fixed as 235 and 225nm respectively, using a Shimadzu UV–Visible spectrophotometer (model UV-1800) with quartz cells. In this proposed method both these drugs obeyed linearity individually and in mixture within the concentration range of 1- 10 μg ml-1 for tamsulosin and 12.5 - 100 μg ml-1 for finasteride, with a correlation coefficient value of  0.9992 and 0.9994 for tamsulosin and finasteride respectively. The low relative standard deviation values indicate good precision and high recovery values indicate accuracy of the proposed method. The proposed method had been applied to the determination of drugs in commercial formulations. Assay results were in good agreement with label claim. The method was validated according to the ICH guidelines.

Keywords: UV spectrophotometric method, finasteride, tamsulosin, simultaneous determination. 

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