DOI: 10.21276/ajptr
Mon, 22 Apr 2019

Formulation and optimization of Metformin hydrochloride matrix tablets using natural polysaccharide blend for sustained release drug delivery: a factorial design optimization approach

Dharmendra Solanki1*, Surendra Kumar Jain2, Sujata Mahapatra3

1.Charak Institute of Pharmacy, Mandleshwar Khargone M.P., India

2. Sagar Institute of Research and Technology, Bhopal, M.P., India.

3. Khallikote (Auto.) College, Berhampur. Orissa India


The aim of this investigation was to develop and optimize Metformin HCl matrix tablets for sustained release application by response surface methodology based on two factor-three response factorial design. The effects of the amounts of polysaccharide from tamarind and polysaccharide from jackfruit in Metformin HCl matrix tablets on the properties of Metformin HCl sustained release matrix tablets drug release was analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized Metformin HCl matrix tablets showed prolonged sustained release of Metformin HCl over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism.

Keywords: Metformin, Matrix tablet, Sustained Release, Factorial, Design of experiment, Jackfruit, Tamarind, Polysaccharide

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