DOI: 10.21276/ajptr
Wed, 20 Mar 2019

Interactive Effect of Combined Aqueous Leaf Extracts of Ocimum gratissimum and Vernonia amygdalina on Fasting Blood Glucose in Rabbits

Samuel Chidi Iwuji1*, Author Nwafor2, Princewill Rewhuamwhu Chike2, Iwuji Ngozi Grace Iwuji3, Joakin Chidozie Nwaokoro

1. Department of Biomedical Technology, School of Health Technology, Federal University of Technology Owerri, Nigeria.

2. Department of Human Physiology, Faculty of Basic Medical Sciences, College Of Health Sciences, University Of Port Harcourt, Nigeria.

3. JONGRES Biomedical Laboratories (Zoological Division) Owerri, Naze P.A. Owerri- North, Imo State Nigeria.

4. Department of Public Health Technology, School of Health Technology, Federal University of Technology Owerri, Nigeria


The leaves of Ocimum gratissimum (OG) and Vernonia amygdalina (VA) had been of medicinal interest mainly due to their respective antioxidant and antihyperglycaemic properties. A daily dose of 0.5gKg-1 body weight aqueous leaf extracts of OG, VA and 50:50 (OG+VA) was orally administered to three different rabbit groups for 28 days, fed ad libitum. The control group was given only 2mlKg-1 of normal saline daily. Fasting blood glucose concentration was monitored with a digital glucometer. From the SPSS (version 15) multivariate analysis (p=.05), results showed that the mean fasting blood glucose concentrations of normal rabbits used was 5.98±0.5 mMolL-1. Only VA lowered fasting blood glucose within 24 hours and maintained the hypoglycaemia for 72 hours; VA potentiated OG after 72 hours and later synergistically lowered fasting blood glucose concentration. This study suggested that VA and (OG+VA) were time-dependent hypoglycaemic: while consumption of VA had acute effect, (OG+VA) could preferably be used for longer prophylaxis of diabetes. Therefore, further researches are recommended on the efficacy of this herbal combination therapy.

Keywords: Ocimum gratissimum, Vernonia amygdalina, Interactive effects, blood glucose, Rabbits

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