DOI: 10.21276/ajptr
Wed, 18 Jul 2018

Anti inflammatory activity of aqueous extract of fruits of garcinia pedunculata in experimental animals.

Ravi Mundugaru1*, Febin Joy2, Shrinidhi R3, Lipika Das4, Sudhakara1, Ravishankar B5.

1. Dept of Pharmacology & Toxicology, 5Professor of Experimental Medicine and Director, Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi, India 574 118

2. Department of Dravyaguna, Munial College of Ayurveda, Manipal, India 574 118

3.Department of Agadathantra, Sri Dharmasthala Manjunatheshwara College of Ayurveda, Udupi, India 574 118

4. Department of Pharmacology, Sapthagiri Medical College Bangalore India 574 118


ABSTRACT

Garcinia pedunculata is a medicinal plant commonly known as Amlavetasa, belonging to the family Clusiaceae. The fruit of Garcinia pedunculata were used in the diet as a spice. It has been used as folk remedy in different ailments such as chronic catarrh, asthma, cough, bronchitis, cardiotonicand fever. The present study has been carried out to evaluate the anti inflammatory activity of aqueous extract of fruits of Garcinea pedunculata by carrageenan induced paw edema method. Eighteen healthy wistar albino rats were divided into three different groups of six rats each. Group I administered with normal tap water (5ml/kg) served as normal control. Group II administered with Ibuprofen 100mg/kg served as reference standard and group III administered with aqueous extract of fruits of Garcinea pedunculata(400mg/kg). In Acute oral toxicity study there was no mortality in any dose up to 2000mg/kg. The aqueous extract of fruits of Garcinea pedunculata has shown significant anti inflammatory activity by significantly decrease in the paw volume recorded at three different time interval compared with control group (**p< 0.01). It can be concluded that aqueous extract of fruits of Garcinea pedunculatahas potent anti inflammatory activity and there is a need for further scientific investigation to explore its anti inflammatory activity.

Keywords: Garcinia pedunculata, Amlavetasa, Ibuprofen, Bronchitis, Anti- inflammatory, Carrageenan.


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