DOI: 10.21276/ajptr
Thu, 21 Mar 2019

Solvent-Free Microwave Assisted Fluorspar Mineral Reusable Catalyst for the Synthesis of Pyrimidines

Venkateshwarlu Jetti1*, Praveen Chidurala1, Jyotsna S. Meshram1

1. Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur – 440 033, Maharashtra, India.


An easy solvent-free synthesis of pyrimidine derivatives from aldehydes, aceto acetanilide and urea/thiourea by using fluorspar mineral as catalyst has been described under microwave irradiation. The salient features of this one-pot protocol are short reaction times (4-5 min), excellent yields, cleaner reaction profiles and simple work-up. Also, the catalyst can be reused without any reduction in efficiency.

Keywords:  Biginelli reaction, Pyrimidines, Fluorspar catalyst, Microwave irradiation.

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