DOI: 10.21276/ajptr
Wed, 20 Mar 2019

Development and Validation of UV Spectrophotometric Method for Estimation of Efavirenz in Bulk and Pharmaceutical Tablet Dosage Form

Mahipalsingh M. Bayas1*, Sugandha V. Mulgund1

1. Department Quality Assurance Techniques, STES’s, Sinhgad College of Pharmacy, Vadgaon (Bk.), Sinhgad Road, Pune - 411041, Maharashtra, India.


A simple, accurate and precise UV spectrophotometric method has been developed for the quantitative estimation of Efavirenz in bulk and tablet dosage form. The λmax was found to be 239 nm. Beer’s law was obeyed in the concentration range of 10-20μg/ml. The regression equation was Y=0.052x-0.113 with value of R2 as 0.996. The method showed good linearity, accuracy and reproducibility. Accuracy as expressed mean percent recovery ± standard deviation was found to be 95.29% ± 0.0429. Percent relative standard deviation values for the intra-day and inter-day precision studies were found to be 0.23 and 0.31, respectively. The limit of detection and limit of quantitation values were found to be 1.39 and 4.22, respectively. Assay of Efavirenz in tablet formulation was performed and percent purity of tablet was found to be 98.65% ± 0.0078.

Keywords: Efavirenz, UV spectrophotometry, Validation.

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