DOI: 10.21276/ajptr
Wed, 23 Jan 2019

MW Induced Preparation of Acridin-9-Yl-Bis-Benzothiazol-2-Yl-Amines and Antituberculosis Activity

Pravin R. Kawle1*, Pradip P. Deohate1

1.Research Laboratory of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science,  Akola-444 001, India


Preparation of new series of acridin-9-yl-bis-benzothiazol-2-yl-amines have been developed by intra-molecular cyclization of 1-acridin-9-yl-1-benzothiazol-2-yl-3-aryl thiourea with bromine in acetic acid and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis by BACTEC radiometric method. Constitutions of compounds were confirmed by FTIR, 1H-NMR, 13C-NMR spectral methods. Simple work-up procedure and excellent yield of the products are the merits of the route.

Keywords: MW organic reactions, benzothiazole, antituberculosis.

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