DOI: 10.21276/ajptr
Fri, 25 May 2018

Formulation, Optimization and Evaluation of Self Emulsifying Drug Delivery System of Diclofenac Sodium Tablets

Digvijay Singh1*, Vikram Singh1, Divyal Juyal1, Geeta Rawat2

1.Himalayan Institute of Pharmacy & Research, Dehradun, Uttarakhand

2.Department of Pharmaceutical Science, HNB Garhwal Central University, Srinagar, Uttarakhnad


ABSTRACT

Various strategies have been widely investigated to enhance the solubility of poorly soluble drugs. These strategies increase the clinical efficacy when the drug is administered orally. Around 40% of novel chemical entities show evidence of poor aqueous solubility and their bioavailability becomes low. Thus to overcome this problem new technologies are applied. This new technologies improve the solubility of those drugs whose water solubility is poor. This new technology is known as SEDDS. Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. It can be orally administered in soft or hard gelatin capsules. This formulation enhanced bioavailability due to increase the solubility of drug and minimizes the gastric irritation.

Keywords: Isotropic Mixture, SEDDS, Oils, Surfactants, Solvents, Co-solvents


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