DOI: 10.21276/ajptr
Thu, 24 Jan 2019

Formulation Characterization and Evaluation of Bioadhesive Orodispersible Film of Enalapril Maleate For Soft Palate Drug Delivery

Sameeksha Misra1, Sayantan Mukhopadhayay1* ,  Ganesh K Bhatt1, Preeti Kothiyal1

1.Division of Pharmaceutical sciences S.G.R.R.I.T.S, Patel  nagar Dehradun Uttrakhand 248001


The present experimental study involves the preparation and characterization of  Orodispersible film of enalapril maleate. In this method HPMCK100 and propylene glycol are used to formulate orodispersible film and two disintegrating agent was used by using solvent casting method. Enalapril maleate is a antihypertensive drug which class of ACE inhibitor (Angiotensin converting enzyme). It is used in the treatment of hypertension congestive heart failure. It show low bioavailability due to high hepatic first pass metabolism so the soft palate drug delivery provide an excellent route to deliver the drug into systemic circulation and the present experimental work to formulate bioadhesive orodispersible of  enalapril maleate to improve the therapeutic efficacy, patient compliance and its bioavailability by avoiding the first pass metabolism. After proper preformulation studies various orodispersible film which were prepared subjected for several evaluation study like thickness, weight uniformity, surface pH, drug uniformity, folding endurance, In vitro disintegration time the drug is rapidly disintegrate within seconds. It means it show that best for the those patient who have difficult to swallowing the drug and .Invitro dissolution  study of prepared orodispersible film was carried out in phosphate buffer 7.4 as a medium and it was clearly observed that the F6 formulation  a best formulation because it rapidly drug release. All the formulation provide a well controlled drug release at a sustainable rate. From the experimental result it was clearly concluded that orodispersible film of enalapril maleate may use as an effective drug delivery with an enhance bioavailability.

Keywords: Orodispersible film, Hydroxypropylmethylcellulose(HPMCK100), Crosspovidone, Solvent casting , Emalapril maleate

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