DOI: 10.21276/ajptr
Fri, 17 Aug 2018

Effect of Acetone Root Extract of Canthium parviflorum Lam. in N-Nitroso N-Methyl Urea Induced Mammary Carcinoma in Female Sprague-Dawley Rats

John. D. Milton1*,   M. Alvin Jose2

1. Prist University, Vallam, Thanjavur-613403. Tamil Nadu, India.

2. Swamy Vivekananda College of Pharmacy, Elayampalayam, Tiruchengode-637205. Namakkal District, TamilNadu, India.


ABSTRACT

The objective of the study was to evaluate the anticancer activity of Acetone root extract of Canthium parviflorum Lam. (ARECP) in N-Nitroso N-methyl urea (NMU) induced mammary carcinoma in female Sprague-Dawley rats. Thirty virgin female Sprague-Dawley rats of 55 day old were divided into five groups (normal control, disease control, ARECP 200 mg/kg, ARECP 400 mg/kg, tamoxifen10 mg/kg) of six animals each. The mammary carcinoma was induced by two intraperitoneal doses of N-Nitroso N-methyl urea (NMU) (50mg/kg/body weight each) in 0.9% Nacl (maintained at 40C) at 55 day of age and 4 week after the prior administration. The drug ARECP was administered in two doses, 200 mg/kg, and 400 mg/kg orally and compared with the oral dose of tamoxifen (10 mg/kg). ARECP 200 mg/kg, 400 mg/kg, and tamoxifen10 mg/kg decreased the tumor incidences by 33.33%, 50%, and 83.33% and the total number of tumors in group by 33.33%, 60% and 93.33% respectively, when compared to the disease control. ARECP 200 mg/kg, 400 mg/kg, and tamoxifen 10 mg/kg decreased the average tumor burden by 65.06%, 92.16% and 95.72% and average tumor volume by 62.25%, 85.18%, and 93.73% respectively, when compared to disease control group. The results concluded that ARECP prevent the mammary carcinogenesis induced by N-Nitroso N-methyl urea in female Sprague-Dawley rats.

Keywords: Mammary Carcinoma, Canthium parviflorum, tamoxifen, N-Nitroso N-methyl urea.


[PDF]   Viewed: 565   Downloaded: 85
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter