AJPTR
Tue, 19 Mar 2024

October 2016 Issue 5

1

Approaches of Nanomedicine in Cancer Therapy

Kola Prasanna Yadav*1, Bojedla Naveena1, Nemarugommula Prunvitha1, Thirungiri Praveenkumar2

1.Browns College of Pharmacy, Affiliated to Kakatiya University-Warangal, Ammapalem (V), Khammam, Telangana State, Pin – 507 305.

2

Zika Virus Disease-Epidemiology, Diagnosis, Prevention and Treatments

CM Jamkhandi1*, Kambli MR1, Hirave PA1, JI Disouza1

1.Tatyasaheb Kore College of Pharmacy, Warananagar Tal- Panhala, Dist- Kolhapur M.S. India 416113 

3

Comparative evaluation of postoperative pain with different intracanal medicaments – A Systematic Review

Sanu N1*, Sindhu Ramesh1

1.Department of Conservative Dentistry and Endodontics, Saveetha Dental College, Saveetha University, Chennai, India.

4

Catalytic Oxidation of Schiff Base metal Complexes: A Review

Ab. Rashid Wani1*, Haroon Rashid Boked1, Ghulam Mohammad Jan1, Mukhtar Ahmad Wani2, Nazir Ahmad Wani1

1. Department of Chemistry, Govt. Degree College Boys Anantnag J&K (India)

2.Department of Chemistry, Govt. Degree College for Womens Anantnag J&K (India)

5

Prickly Amaranth (Amaranthus spinosus Linn.): a Review on Phytochemistry and Pharmacological Activities

Sangita Boro1*, Bhriganka Bharadwaj1, B.G. Unni2

1.Department of Microbiology, Assam Down town University, Sankar Madhav Path, Gandhi Nagar, Panikhaiti, Guwahati 781026, Assam, India.

2.Research Cell, Assam Down town University, Sankar Madhav Path, Gandhi Nagar, Panikhaiti, Guwahati 781026, Assam, India

6

GC-MS Study and Pharmacognostic Study of Pithecellobium Dulce Leaves

Anil F.Bobade*

Dept of Industrial Chemistry, Arts, Science and Commerce College, Chikhaldara (MH) India.

7

Synthesis and evaluation of quinolone derivatives as potential antibacterial agents

Mohammad Shoeb1*, Rahimullah Shaikh1

1.Government Vidhabha Institute of Science & Humanities, Amravati 444604, India

8

The role of FSH, LH, and Prolactin Hormones in Female Infertility

Ali A. Al-Fahham1*,  Hisham Q. Al-Nowainy1

1 University of Kufa, Faculty of Nursing , Basic Science Department

9

The Effects Parabens on the Estrogenic Receptors Behavior in Human Breast Adenocarcinoma MCF-7 Cell Line.

Maryam Nakhjavani1, Nastaran Nikounezhad1, Farshad H. Shirazi1,2*

1.Department of Pharmaco/Toxicology, School of Pharmacy, Shahid Beheshti Medical University, Tehran, Iran

2.Pharmaceutical Sciences Research Center, Shahid Beheshti Medical University, Tehran, Iran

10

Synthesis, Characterization and Biological Evaluation of New Glycosyl Thiocarbamides Derived from Glycosylamines

Sneha U. Jadhao*1 , Shirish P. Deshmukh1

1. P. G. Department of Chemistry, Shri Shivaji College, Akola-444001. (M. S)., India

11

Formulation and Evaluation of Lornoxicam Topical Gel

Shereen A. Eladawy1, Amal S. M. Abu El-Enin1, Soha A. Ismail2, Eman R. Mishrif2*

1.Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy,

Al-Azhar University, Nasr City, Cairo, Egypt.

2. National Organization for Drug Control and Research, El-Dokki, Egypt.

12

Simultaneous Determination of Triamterene and Hydrochlorothiazide In Human Plasma by Liquid Chromatography-Mass Spectrometry

Dhananjay Sable1,2*, Abhas Tiwari1,2, Milind Bagul2, Sailendra Goswami1,2

1. Department of Doctoral Studies, R. K. University, Rajkot, India

2. Raptim Research Ltd., A-242, TTC Industrial Area, Mahape MIDC, Navi Mumbai, India

13

Comparative Study of Antihypertensive Drugs At Tertiary Care Hospital

R.Sivasakthi*1, W.D.Sam Solomon1, Nousheen shafi1, Mohammed Aslam1. Nithiyan.P2

1. RVS College of Pharmaceutical Sciences, Coimbatore – 641 402.

2.Interventional Cardiologist, KG Hospital and post graduate research Institute, Coimbatore – 641 018.

14

Lifesaving effect of lidocaine on Odontobuthos Doriae scorpion envenomation in mice.

Maryam Nakhjavani1, Hossein Vatanpour1*, Fatemeh Shahriari1, Baharak Mohamadzadehasl1

1. Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti Medical University, Tehran, Iran.

15

Synthesis and pharmacological evaluation of 2-substituted 1,3,4-oxadiazole derivatives as antimicrobial agents

Shivi Bhatia1, Amandeep Kaur1 and Monika Gupta1*

1.Department of Pharmaceutical Chemistry, ASBASJSM College of Pharmacy, Ropar- 140111, India

16

Changes in Anti-Oxidative Enzyme and Hematological Parameters of Rohu (Labeo Rohita) Fingerlings Exposed To Ivermectin

Md Aklakur*1, N. P. Sahu1, S. Dasgupta1, M.M. Gatne2 and A. K. Pal1

1. Central Institute of Fisheries Education, Versova, Mumbai 400 061, India

2. Department of Pharmacology & Toxicology. Bombay Veterinary College, Parel Mumbai, India

17

Development and Validation of Stability-Indicating RP-HPLC Method for Determination of Fluindione

Mrinalini C. Damle*, Mahesh G. Thakare

1.AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune-411001.

18

Seasonal Food Security Through Edible Leafy Weeds to Local Inhabitants of A Village In Ranchi District of Jharkhand During Rainy Season

Lal Ratnakar Singh

Jharkhand Rai University, Ranchi, Jharkhand

19

Anticancer and antiviral potential of folic acid conjugated with silver and gold Nanoparticles produced by Thermoduric Bacillus alcalophilus subsp halodurans

Rawhia Arafa

Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Egypt

20

Characterization of antioxidant property and Chemical compositions of Lagenaria Siceraria stand. Fruit extract

Sarang Sunil Mahamuni*1 ,Vishal Sanjay Savant2

1.Satara College of Pharmacy Satara

2. Sant Gajanan Mahajaj College of Pharmacy. Gadhinglaj Kolhapur

21

A Development and Validation of RP-HPLC Method For Simultaneous Estimation of Nadifloxacin and Clobetasol Propionate In Its Pharmaceutical Dosage Form

Nidhi Patel*1, Pooja Patel1, Dhananjay Meshram1

1. Department of Quality assurance, Pioneer Pharmacy Degree College, Vadodara-390019, Gujarat, India.

22

Evaluation of antioxidant potential of grains of Paspalum scrobiculatum Linn.

Swati Sharma*1, Jyoti Saxena2

1.Sarojini Naidu Govt. Girls PG (Auto) College, Shivaji Nagar, Bhopal, Madhya Pradesh- 462016

2 Institute for Excellence in Higher Education, Kaliyasot Dam, Kolar Road, Bhopal, Madhya Pradesh- 462016

23

RP-HPLC Method Development for Determination of Vasopressin From Nanoparticles

Dipti Desai1,*, Dushyant Shah2

1.Department of Pharmaceutics, Pioneer Pharmacy Degree College, Gujarat Technological University, Vadodara, Gujarat, India,

2.Department of Pharmaceutics, APMC College of Pharmaceutical Education & Research, Himatnagar, Gujarat, India

24

Evaluation and Determination of Antifungal Potentials of Sap of Azadirachta Indica

Tribhuvan Singh1*, Syed Imran Ul Haq1, K. Rajeshwar Dutt1, Ibrahim Makintami Ibrahim1

1.Guru Nanak Institutions Technical Campus - School of Pharmacy Ibrahimpattnam, Hyderabad- 501506

25

Synthesis, Characterization and Antimicrobial Studies of Schiff Base Complexes of 1-(5-Chloro-2-Hydroxy-4-Methylphenyl)Ethanone

Jaishri N. Bavane*1 and Rahul B. Mohod 1

1. P. G. Department of Chemistry, Shri Shivaji College of Arts, Commerce and Science, Akola- 444003 (M. S.).

26

Effect of d-Limonene on behavior and brain oxidative stress in cerebral-ischemia reperfusion injury of mice

Harpreet Kaur1, Nitin Bansal1*

1.Department of Pharmacology, ASBASJSM College of Pharmacy, Bela (Ropar)-140111

27

Benzimidazole – A Potent Antimicrobial Agent

Pullagura M Krishna Prasad1, Avdhut Kanvinde S1 and Raja S*2

1. Pfizer Limited, Pfizer Center, Mumbai-400 102, Maharashtra, India.

2.Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM University,  Visakhapatnam-530 045, Andhra Pradesh, India.

28

Formulation and Evaluation of In Vitro Blood-Brain Barrier Penetration of Emtricitabine Niosomes Using Immobilized Artificial Membrane Phosphatidyl Choline Column Chromatography

Santha Sheela Natarajan Bhargavi 1*, Nappinnai Mohanavelu2, Panneer Selvam Perumal1, Sundhararajan Ranganathan3

1.C.L.Baid Metha College of Pharmacy,  Jyothi Nagar, Thoraipakkam,  Chennai - 600 096.

2.Surya School of Pharmacy, Surya Group of Institutions, Vikravandi,  Villupuram Dist - 605 652.

3. Mohammed Sathak A.J. College of Pharmacy, Medavakkam Road, Sholinganallur, Chennai - 600 119

29

Development and Validation of RP-HPLC Method for the Quantitation of Ticagrelor Using Box-Behnken Experimental Design

Rahul P. Chilbule1 and Rajendra B. Kakde1*

1.Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur- 33, Maharashtra, India

30

Development and Evaluation of Olmesartan Medoxomil Solid SEDDS: In Vivo Bioavailability Studies

B. Usha sri*1, Y. Indiramuzib2, D.V.R.N. Bhikshapathi3, P. Varalaxmi3

1. Nizam Institute of Pharmacy, Deshmukhi, Pochampally (M), Nalgonda, Telangana- 508284.

2. Sri Padmavathi Mahila Viswavidyalayam, Tirupati, Andhra Pradesh.

3. Vijaya College of Pharmacy, Hayath nagar, Hyderabad-501511

31

In Vivo Antianaphylactic Activity of Different Extracts of Glycyrrhiza Glabra on Mesenteric Mast Cells of Rats

C.Girish1, Y. Narsimha reddy2*.

1. Sri Venkateshwara University, Tirupati - 517502. A.P, India.

2. University College of pharmaceutical sciences, Kakatiya University, Warangal - 506009, A.P, India.

32

An Effective Novel Strategy of Combined Plants Extract for the Treatment of Parkinson's Disease

Parwez Alam1*, Jyoti Gupta2, Seema Firdouse1

1. Singhania University, Pacheri Bari, Jhunjhunu- 333515, Rajasthan, India.

2. MVN University, Palwal-121105, Haryana, India.

33

Atorvastatin Calcium Solid Dispersion in Floating Tablets for Hypolipedmic Effect.

Al Zahraa G. Al Ashmawy1, Marwa H. Abdallah1,2*, Hanan M. El Nahas1

1. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

2. Department of Pharmaceutics, College of Pharmacy, Hail University, Hail, KSA.

34

Development of Pulsatile System of Nabumetone for Effective Management of Colonic Spasms

Bhargavi ganiwada*1, Suresh moka2, Raju Venkata Krishna1, Manogna.K3,

1.University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, AP, India.

2.Adarsa College of Pharmacy, G. kothapalli, East Godavari, AP, India.

3.Hindu college of pharmacy ,Guntur

35

Flavonoids insulinogeneic action” may be “A promising alternative for diabetes” management

Nandhakumar Loganathan1*, Mohan Sellappan2

1. Department of Pharmacy, Shri Jagadish Prasad Jhabharmal Tibrewala University, Jhunjhunu, Rajasthan, India.

2. Faculty of Pharmacy, Karpagam college of Pharmacy, Coimbatore, Tamilnadu, India.

36

Effects of intraperitoneal administration of ivermectin on antioxidative enzymes and blood parameters in Rohu (Labeo rohita)

Md Aklakur*1, N. P. Sahu1, S. Dasgupta1, M.M. Gatne2 and A. K. Pal1

1.Central Institute of Fisheries Education,Versova, Mumbai 400 061, India

2 .Department of Pharmacology & Toxicology. Bombay Veterinary College, Parel Mumbai, India

37

Phytochemical screening, Antimicrobial and Antioxidant activity of whole extract of Cardiospermum halicacabum Linn. (Sapindaceae)

M. O. Malpani1*, P. R. Rajput2, P. S. Pande1, M. M. Sapkal1

1. Department of Chemistry, Shankarlal Khandelwal Arts, Science and Commerce College, Akola 444 002 (M.S), India.

2. Department of Chemistry, Vidya Bharati Mahavidyalaya, Amravati

38

Process Validation of Extra Power Pain Control Caplets

Prajapati PR1*, Desai N 1, Modi VS1, Tarasankar Basuri1

1.SSR college of Pharmacy, Sayli road, Silvassa-396230

39

Enhancement of Solubility and Bioavailability of Glimepiride Using Solid Dispersion Technique

V. Abhishiktha1*, M. Sudhakar1, Vinay Umesh Rao1

1.Malla Reddy College of Pharmacy, Maisammaguda, Post Dhulapally, Secunderabad- 500014, India

40

Synthesis of 2,3,5-Trisubstituted 1,3,4-Oxadiazole Via Cyclization of 5-Fused Heteryl Pyrazole-3-Carbohydrazone having Quinolin-3-yl Moiety and their Antibacterial Activity

Mohammad Idrees*1 Roshan D. Nasare2 , Naqui J. Siddiqui1

1.Department of Chemistry, Government Institute of Science, Nagpur (M.S.), India

2.Department of Chemistry, Government Science College, Gadchiroli (M.S.), India

41

Trend of Smoking In Students of Ras Al Khaimah, UAE

Shahnaz Usman1 ⃰, khawla Al Awad1, Muaadh Al Saeedi1, Hamam Al Naemi1,Huma Zaidi1

1.Department of Pharmaceutics, RAK College of Pharmaceutical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE

42

Synthesis and Biological Studies of 4-(4-chloro-1-hydroxynaphthalen-2-YL)-6- aryl-5,6-dihydropyrimidin-2(1H)-one

V.M.Sherekar1 , S.E.Bhandarkar1* 

1. Govt.Vidarbha Institute of Science and Humanities, Amravati- 444604,(M.S.) (Cell : 9096112804)

43

Preparation and In Vivo Evaluation of Extended Release Trilayer Matrix Tablets Containing Simvastatin Solid Dispersions

A.Thirupathaiah*1,  R. Shyam Sunder2

1.Osmania University, Hyderabad-500007, Telangana, India.

44

Analytical Approach to Develop and Validate Stability Indicating HPLC Method for Simultaneous Estimation of Tolperisone Hydrochloride and Diclofenac Sodium In Combined Pharmaceutical Dosage Form

Bhavsar Ankita1*, Bhavsar Ayushi 1

1.Sat Kaival College of Pharmacy, Sarsa, 388365, Ta. Dist – Anand, Gujarat, India.

45

Preparation, Spectrachemical Characterization and Antimicrobial Activity of Some New Acredinediones Derivatives

Ghulam Mohammad Jan1*, Shakeel Ahmad Khanday1 , Samina Akthar2

   1. Govt. Degree College Boys anantnag J&K (India)

2. Govt. Degree College for Women’s MA road Srinagar J&K (India)

46

Design, Optimization and In Vivo Evaluation of Granisetron HCl Mouth Dissolving Films

S. Jyothi Sri1, D.V.R.N.Bhikshapathi2*         

1.Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500072, Telangana State,India.

2.Dept of Pharmaceutics, CMR College of Pharmacy, Kondlakoya (V), Medchal Road, Hyderabad-501401, T.S, India

47

Evaluation and Optimization of In Silico Designed PDE4B Modulators

Daniel Attard1, Claire Shoemake1, John Vella1, Paweł Żmudzki2, Grażyna Chłoń-Rzepa2, Elżbieta Wyska3

1.Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida

2.Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland

3.Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland

48

Synthesis of Highly Substituted Pyrrolidines via Double Michael Addition Reaction and its Anti-Microbial Activity

Nandkishor Chandan

Department of Chemistry, Siddharth College of ASC, Fort Mumbai, M.S. India

49

Appraisal of the Anticancer Activity of Various Formulations of Triphala Against Ehrlich Ascites Carcinoma In Mice

Somayeh Afsah Vakili*1, Ajay George 2, Syed Fayazuddin1

1. Visveswarapura Institute of Pharmaceutical Sciences, Bangalore-560070, Karnataka, India.

2., St. Johns Pharmacy college, Bangalore-560104, Karnataka, India

50

Phytochemical and antiulcer potential of ethanolic leaf extract of houttuynia cordta, thumb.

Mrinmoy Basak1*, Biplab Kr. Dey1

1.Department of Pharmacy, Assam down town University, Pnikhaiti, Guwahati, Assam, Pin-781026

51

Radiosensitization effect of Selenium on the ''Warburg effect'', Metabolism of hypoxic Oral Squamous cell Carcinoma

Sonaa Elango1*, Usha Subbiah2

1.Dept of Life Science,School of Natural Sciences, University of Suwon,312, Wau-ri, Bongdam -eup, Hwaseong-si, Gyeonggi - do, 445-743.Republic of Korea.

2.Human Genetics Laboratory, Central Research Facility, Sree Balaji Dental College and Hospital and Sree Balaji Medical College and Hospital, Barath University, Chennai

52

Anti-Angiogenic Activity of L-Type Voltage Gated Calcium Channel Blocker, Nifedipine: An In-Vitro and In-Vivo Study

Chandana Kamili *1, K. Ravi Shankar 2, Uma Maheshwararao Vattikutti 3

1.Department of Pharmacology, CMR College of Pharmacy, Hyderabad- 501401 (Telangana),

2. Department of Pharmacology, Sri Sai Aditya Institute of Pharmaceutical Sciences and Research, Surampalem. (Andra pradesh)India.

3. Department of Pharmacognosy, TRR College of Pharmacy, Hyderabad- 500079 (Telangana), India.

53

Isocratic RP-HPLC Method Development, Validation and Stability Indicating Studies for Simultaneous Determination of Escitalopram and Clonazepam In the Combined Dosage Form

G.V.Adilakshmi1, P.V.V. Satyanarayana2*

1. Vijaya Institute of Technology for Women, Vijayawada-521108 (A.P), India.

2. Retd. Professor, Acharya Nagarjuna University, Guntur-522510(A.P), India.

54

Nephroprotective Activity of Poly Herbal Methanolic Extract Against Gentamicin-Induced Nephrotoxicity and Renal Dysfunction In Experimental Rodents

V.V. Rajesham1*, Balusu Haarika2, DVRN Bikshapathi1, T. Rama Mohan Reddy1, M.Srinivasa Chandramouli3

1.CMR College Pharmacy, Kandlakoya, Medchal road, Hyderabad-501401, Telangana state, India.

2.Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya, Tarnaka, Secunderabad-500001, Telangana state, India.

3.Gandhi hospital, Musheerabad, Hyderabad, A.P., India.

55

Development of Validated HPTLC Method for the Standardization of Euphorbia Hirta using Gallic Acid, Rutin and Quercetin as Phytochemical Markers

A.Suganthi1*, N. Ramu1, K. Arthi 1, T.K. Ravi1

1.Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, 395, Sarojini Naidu Road, Coimbatore-641 044

56

A Review On Isatin and Its Pharmacological Profile

Rekha Pharswan*1, Meenu Chaudhary1

1. Department of Pharmaceutical Science, Shri Guru Ram Rai Institute of Technology & Science, Patelnagar, Dehradun.

57

Antilithiatic activity of Grewia asiatica by Sodium oxalate induced Urolithiatic model

P. Veeresh Babu1*, M. Vamsi krishna1, M. Ganga Raju1, P. Venkanna1

1.Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana

58

Preparation and Photochemical Studies of Schiff Base Metal Complexes

Haroon Rashid Boked1, Ghulam Mohammad Jan1*

1.Department of Chemistry, Govt. Degree College Boys, Anantnag Jammu & Kashmir (India)

59

Synthesis, Surface Morphological Studies and Biological Application of Polymer Supported Metal Complex

Shakeel Ahmad Khanday1*, Samina Akthar2,M.Y.Peerzada3

1.Department of Physics,   Govt. Degree College Boys Anantnag J&k (India)

2.Department of Physics, Govt. Degree College for Women’s MA road Srinagar J&k (India)

        3.Department of Zoology, Govt. Degree College Boys Anantnag J&k (India)

60

Chemical and Biological Properties of vanadium and Iron compounds in relation to cancer treatment and other Biological Applications- A review

Ab. Rashid Wani1*, Ghulam Mohammad Jan2

1.Department of Chemistry, Govt. Degree College Boys Dooru Anantnag J&k (India)

2.Department of Chemistry, Govt. Degree College Boys Anantnag J&k (India)

61

Synthesis, Characterization and Mechanism of Catalytic Oxidation of Dendrimer metal Complex

Mir Shabeer Ahmad1*, Ghulam Mohammad Jan1

1.Department of Chemistry, Govt. Degree College Boys Kulgam J&k (India)

62

Preparation Characterization and Antifungal Activity of Chitosan Thiozole Metal Complex

Mir Shabeer Ahmad1*, Ghulam Mohammad Jan2, G.M.Mir3

1.Govt. Degree College boys kulgam J&K (India)

2.Govt. Degree College Boys anantnag (J&K)

3.Govt. Women's College anantnag J&K(India)

63

Drugs Contain Metals – A short Review on the Application of drug Contains Gold

Ab. Rashid Wani*1, Ghulam Mohammad Jan1

1.Department of Chemistry, Govt. Degree College Boys Dooru Anantnag J&k (India)

64

Preparation, Morphological and Thermal Study of Cysteine Amino acid Metal Complexes

Ghulam Mohammad Jan1*, Fayaz Ahmad Bhat1 , Haroon Rashid Boked1

1.Department of Chemistry, Govt. Degree College Boys, Anantnag Jammu & Kashmir (India)

65

Catalytic Oxidation of Phenols, Benzyl alcohols and Olefins using Schiff Base Metal Complexes- A review

Fayaz Ahmad Bhat1, Ghulam Mohammad Jan1*, Haroon Rashid Boked1

1.Department of Chemistry, Govt. Degree College Boys, Anantnag Jammu & Kashmir (India)

66

Ingestion Effect of pathogens on Primary Metabolites of Tinospora cordifolia.

Abhimanyu Sharma1* and Amla Batra1

1.Plant tissue culture and Biotechnology lab, Department of Botany, University of Rajasthan, Jaipur, India

67

Inclusion of Diacerein with cyclodextrin carriers: Preparation, physicochemical characterization, cytotoxicity assessment and pharmacological evaluation

Abhishek Pathak1*, Sadhana J Rajput1

1.TIFAC Centre of Relevance and Excellence in NDDS, G H Patel Pharmacy Building, Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara-390 002, Gujarat, INDIA.