DOI: 10.21276/ajptr
Tue, 23 Oct 2018

Nephroprotective Activity of Poly Herbal Methanolic Extract Against Gentamicin-Induced Nephrotoxicity and Renal Dysfunction In Experimental Rodents

V.V. Rajesham1*, Balusu Haarika2, DVRN Bikshapathi1, T. Rama Mohan Reddy1, M.Srinivasa Chandramouli3

1.CMR College Pharmacy, Kandlakoya, Medchal road, Hyderabad-501401, Telangana state, India.

2.Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya, Tarnaka, Secunderabad-500001, Telangana state, India.

3.Gandhi hospital, Musheerabad, Hyderabad, A.P., India.


ABSTRACT

To evaluate Nephrpotective potential of Polyherbal methanolic extraction (Terminalia chebula, tinospora cordifolia, Phyllanthus emblica, Portulaca oleracea) against gentamicin (GM) induced Nephrotoxicity and renal dysfunction. It was observed that the GM treatment induced significant elevation (P<0.001) in plasma and urine urea, creatinine, kidney weight, blood urea nitrogen, renal lipid peroxidation along with significant decrement (P<0.001) in urine output, renal enzymatic and non-enzymatic antioxidants. Polyherbal methanolic extraction 200 and 400 mg/kg treatment to GM treated rats recorded significant decrement (up to P<0.001) in plasma and urine urea and creatinine, renal lipid peroxidation along with significant increment (up to P<0.001) in renal enzymatic and non-enzymatic antioxidants. These finding powerfully supports that Polyherbal methanolic extraction acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GM in the biochemical parameters and thus validates its ethnomedicinal use.

Keywords: Nephroprotective, Terminalia chebula, tinospora cordifolia, Phyllanthus emblica, Portulaca oleracea.


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