DOI: 10.21276/ajptr
Tue, 11 Dec 2018

Pharmacognostic Investigation, Anti-Helminthic Activity and Anti Microbial Activity of Rubus Ursinus

G. Swapna1, B.Manjula1, Md. Faheemuddin2*, Md. Mazher Ahmed3

1.Department of Chemistry, Avanthi Institute of Pharmaceutical Sciences, Hyderabad, India

2. Department of Pharmacy, Smt. Sarojini Ramulamma College of Pharmacy, Mahabubnagar

3. Department of Pharmaceutics, Luqman College of Pharmacy, Gulbarga, Karnataka, India


ABSTRACT

To evaluate the physicochemical parameter. Anti-Helminthic  activity, Anti-Fungal activity and Anti-bacterial activity by various extracts (petroleum ether, chloroform, acetone, methanol) against various gram positive and gram negative bacteria (E.coli, Staphylococcus aureus and Bacillus subtilis) using a standard as Amoxicillin, Anti-Fungal activity (Candida Albicans, Aspergillus) using Ketoconazole and Anti-Helminthic  activity using a standard as Albendazole. The collected leaves of Rubus Ursinus were dried under shade for 10 days and then powdered into coarse particles in a mechanical grinder for further use, Extracted with petroleum ether, chloroform, acetone, methanol. Antihelmentic activity was evaluated on adult Pheritima Posthuma. Earthworms by subjecting to standard drug albendazole at a dose level of 10mg/ml and to the extracts of petroleum ether, chloroform, acetone, methanol at doses of 10mg/ml, 20mg/ml,25mg/ml 30mg/ml and 35mg/ml respectively. Anti-Fungal activity and Anti-bacterial activity was also performed against different bacteria by using disc diffusion method, the zones of inhibition of the extracts using standard as Amoxicillin and Ketoconazole  were determined. The powder leaves of Rubus Ursinus plant was subjected to extraction with four solvents petroleum ether, chloroform, acetone, methanol. High yield was obtained by methanol extracts of Rubus Ursinus plants. The qualitative test for methanol extraction was given positive tests for alkaloids, proteins & aminoacids,Tannins,Glycosides,FlavonoidsSaponins,Carbohydrates,Steroids& terpenoids and Phenolic compounds The anti-helmintic study and anti- fungal study of BlackBerry leaves was observed by using the extract of  methyl alcohol. The anti-bacterial study of various BlackBerry leaves extracts (petroleum ether, chloroform, acetone, methanol)  were found to be effective against various gram positive and gram negative bacteria. The leave part of plant of RUBUS URSINUS was observed for the Pharmacognostic investigation and Potent Anti-helmentic activity and significant Anti-Microbial activity. . The purified components may have even more potency with respect to inhibition of microbes.

Key Words: RUBUS URSINUS, Amoxicillin, Ketoconazole, Albendazole


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