DOI: 10.21276/ajptr
Tue, 19 Mar 2019

A Review on Solubility Enhancement: The Particle Engineering and Technique of Poorly water Soluble Drugs

Kiran Niuratti  Khodke 1*, Kishor Sahebrao Salunkhe 1, Machindra Jayram Chavan1, Amit Vinayak Asati 2

1.Amrutvahini College of pharmacy, Sangamner- 422605, Maharashtra, India.

2.Dr. Reddy’s Laboratory, Hyderabad- 500034, Telangana, India.


In pharmaceutical industry the major problem of dosage form development is low aqueous solubility. In present review the particle engineering concept and solubility, permeability approaches design and method used in improvement of particle size. The different methods are used in particle engineering like supercritical fluid technology, controlled precipitation, and mechanical technique, evaporation precipitation to aqueous solution, freezing technique, and sonication technology etc. discussed. The improvements of aqueous solubility need to be formulation development for dosage form very essential. The BCS class II drugs modified to soluble form for need of bioavailability of drugs. The solid dispersion method with a different carrier improves the solubility.

Keywords: Particle engineering, bioavailability, solid dispersion, solubility.

[PDF]   Viewed: 687   Downloaded: 99
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter