DOI: 10.21276/ajptr
Wed, 26 Sep 2018

Development of Naringenin Nanocrystals for Enhanced Solubility and Bioavailability

Neha Katiyar, 1 Mangla Nand Singh2⃰, Pushpa Yadav2, Haribansh Narayan Singh, 3 Dr. Sudipta Saha, 1 Dr. Subhini A. Saraf1

1.Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India

2.Dr.B.R.Ambedkar Pooja College of Pharmacy, Gorakhpur, Uttar Pradesh, India

3.S.R.Institute of Pharmacy, Bareilly, Uttar Pradesh, India


ABSTRACT

Naringenin is a flavonoid which has been used for its wide pharmacological action from ancient years including as antidiabetic agent. Naringenin is a lipophilic drug (BCS-II) and have low water solubility (1 in 1000), bioavailability (<25%) and have short half-life (t1/2 =1.3 -2.2h). Nanocrystals is an approach to increase the therapeutic performance of poorly water soluble drugs. The purpose of the present study was to prepare nanocrystalss of naringenin to improve bioavailability and increase therapeutic efficacy. Nanocrystalss of naringenin were prepared by antisolvent precipitation method. The stabilizers used to improve aggregation and increase the solubility. Nanocrystals were characterized for particle size, morphology, release profile and thermal analysis.

Keywords: Naringenin, Nanocrystals, Bioavailability, Solubility, antisolvent precipitation.


[PDF]   Viewed: 216   Downloaded: 53 DOI No: 10.21276/ajptr.2018.08.02.08
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