DOI: 10.21276/ajptr
Tue, 25 Sep 2018

Synthesis and Antibacterial Property of Schiff Bases Derived from Toluidine and Benzaldehydes

M. Idrish Ali1*, Sonia Akter Nupur1, Md. Ashrafuzzaman1, Md. Mahbubul Hoque2

1. Department of Chemistry, Mawlana Bhashani Science and Technology University,  Tangail-1902, Bangladesh

2. Department of Environmental Science and Resource Management, Mawlana Bhashani Science and Technology University, Tangail-1902, Bangladesh


ABSTRACT

Schiff bases and their complexes are playing very important role in medicinal chemistry from ancient period because of their broad range of biological activities such as antibacterial, antifungal, antimalarial and antiviral etc. In this research project several Schiff bases have been synthesized from p-toluidine and derivatives of benzaldehyde to investigate the antibacterial activity. The synthesized Schiff bases have been characterized by IR and 1H-NMR spectral analysis. All the synthesized compounds have been screened for their in vitro antibacterial activity against gram (+) and gram (–) bacterial strains by disc diffusion method. Among the synthesized compounds, the compound 5 showed strong efficacy against E. coli and the others showed moderate activity against bacterial strains.

Keywords: Schiff base, p-Toluidine, Benzaldehyde, Antibacterial activity

 


[PDF]   Viewed: 284   Downloaded: 108 DOI No: 10.21276/ajptr.2018.08.01.19
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