DOI: 10.21276/ajptr
Thu, 19 Jul 2018

Hypotensive Activity of Tridax Procubens hydro ethanolic extract: Roles of transport of sodium and potassium in Rat Wistar

Koukoui Omedine, Michodjehoun Loetitia, Hoteyi Ismael, Sezan Alphonse*

 Laboratory of Biomembranes and Cell Signaling University of AbomeyCalavi, 06 BP 3041 Cotonou, Benin.


ABSTRACT

In Africa in general and Benin in particular the population is increasingly confronted with several pathologies such as hypertension. Even though modern medicine is well developed, this population uses traditional medicine because of its low purchasing power. But the lack of mastery of the dosage and its underlying effects remain archaic parameters and deserves special attention from the scientific world from which we have chosen to reflect on Tridax procumbens in order to come up with scientific arguments favorable to the promotion of the «Plant species. The present work was carried out in order to evaluate the effect of hydroethanolic extracts on the plasma and urinary concentrations of potassium, sodium and chloride ions in Wistar rats. After the preparation of the extracts and their gavage, the extraction yield was evaluated, the level of the K +, Na +, and Cl- ions was assayed in three batches of three male Wistar rats. Lots 2 and 3 respectively received doses of 300 mg / kg and 500 mg / kg of single-dose PC in one day, respectively. Control batch 1 received distilled water in place of the extracts. At the same time, they were placed in cages with urine sampling, for the measurement of diuresis. The extraction yield by the hydroethanolic solvent was 16.75%. Extracts at a dose of 300 mg / kg of PC induced hyperkalaemia, with no effect on serum sodium and chloraemia within two hours of administration of the extracts. The diuresis is so insignificant that we can understand that hyperkalaemia, induced bradycardia arising from hyperpolarization of the cells of the pace maker. Its hypotensive property is therefore confirmed.

Keywords: Tridax procumbens, Ionic channels, Hyperkalemia, hypernatremia, Hyperchloremia, Diuresis, Hyperpolarization.


[PDF]   Viewed: 196   Downloaded: 46 DOI No: 10.21276/ajptr.2018.08.01.20
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter