Gymnosporia montana belonging to the family Celastraceae commonly known as Vikalo.  It is a shrub or tree growing wild in dry areas and is commonly found in Gujarat. It is widely used in treating sore, ulcer, gastro-intestinal disorders, toothache, and dysentery. The dried powder of leaf of Gymnosporia montana was subjected to the phytochemical screening for the presence of various phytoconstituents like alkaloids, flavonoids, saponins, tannins, anthraquinones, and carbohydrates, etc. Effectiveness of methanolic extracts of leaf of Gymnosporia montana was evaluated (100, 200 and 300 mg/kg; p.o.) against carrageenan-induced rat paw edema, and cotton pellet-induced chronic inflammation. Further, methanolic fraction of the plant was also evaluated (200 mg/kg; p.o.) in tail flick model using rats as well as acetic acid-induced writhing response using mice. Pretreatment with methanolic fraction showed significant (p