A novel, simple, selective and rugged quantitative method for the determination of Fenofibric acid the active metabolite of fenofibrate  in human plasma (Na2EDTA) using liquid chromatography-tandem mass spectrometric (LC-MS/MS) method has been developed and validated with 200µL human plasma. Fenofibric acid-d6 was used as an internal standard. Analyte and the internal standards were extracted from human plasma by liquid-liquid extraction using Methyl tertiary butyl ether as extraction solvent and ammonium acetate (5mM, pH 2.5) as extraction buffer. The reconstituted samples were chromatographed on a C18 column by using isocratic mobile phase. The method was validated over the concentration range of 79.89–20021.87 ng/mL. The Quattro Premier XE mass spectrometer was operated under the multiple reaction-monitoring mode (MRM) using the electro spray ionization technique for quantification of ion transitions at m/z 317.06/231.00 and 323.24/231.04 for the drug and the internal standard respectively. The method was validated for precision and accuracy, stability, matrix effect, dilution integrity, ruggedness, selectivity and extraction efficiency, and method has been proved to be simple, sensitive, selective, rugged and reproducible. A run time of 2.00 min for each sample made it possible to analyze more than 400 plasma samples per day. The proposed method can be applied for the estimation of the Fenofibric acid in real time plasma samples for pharmacokinetic, drug-drug interaction and toxicological studies.   Key words: Fenofibric acid, Validation, Human Plasma, LC-MS/MS, Electrospray ionization.