It is well known that solid oral dosage forms, particularly tablets, are the most acceptable form of delivering medication. However, some new variations are beginning to emerge such as mini-tablets, which offer formulation flexibility. A multifunctional and multiple unit system for oral use are developed by filling versatile mini-tablets in a hard capsule. Multipulsatile DDS, site-specific DDS, zero-order DDS, slow/quick DDS, and quick/ slow DDS are designed in different ways and are investigated. Mini-tablets are small tablets with a diameter typically equal to or less than 3 mm that are typically filled into a capsule, or occasionally, further compressed into larger tablets. It is possible to incorporate many different mini-tablets, each one formulated individually and programmed to release drug at different sites within the gastrointestinal track, into one capsule. These combinations may include immediate release, delayed release, and/or controlled release mini-tablets. It is also possible to incorporate mini-tablets of different drugs to treat concurrent diseases or combinations of drugs to improve overall therapeutic outcome, while delivering distinct release rates of each according to disease requirements. Mini-tablets combine the advantages of multiparticulate dosage forms with the established manufacturing techniques of tableting. Additional benefits of mini-tablets include excellent size uniformity, regular shape and a smooth surface, thereby offering an excellent substrate for coating with modified release polymeric systems. From this, study it can be concluded that, granules-mini-tablets filled in HPMC capsule systems and coated mini-tablet-in-HPMC capsule system sulphate shows both sustained release as well as immediate release may improve the bioavailability and efficacy of any drugs. Keywords: Mini-tablets, immediate-release, delayed-release, controlled-release, multiparticulate dosage forms.