Asparagus racemosus and Centella asiatica are two very common and well known medicinal plant available in India. Both the plants are traditionally used as antiamoebic drugs. Not only are those, both the drugs used as the herbal treatment of several diseases of human beings. In between them some are really critical disease. Several important phytoconstituents have been already isolated and characterized from both the plants and in between them some are the major active marker for the treatment of above said critical diseases. Instead of all those characters, these two plants have very potent antioxidant property. Here, we have taken an attempt to prepare a formulation of the mixture (50:50) of the aqueous extracts of both the plants and compare the antioxidant property of that formulation and extracts. In this study calcium chloride cross linked alginate microsphere and chitosan coated microsphere have been prepared by using the above said plant extracts and the anti-oxidant property of those formulations were compared with the extracts and also standard drugs. The result therefore reflects that the antioxidant potency of the combined extract entrapped in formulations was almost equivalent to the original extract combinations. This entails despite of the different process control stresses in the manufacturing steps the potency of the polymer entrapped drug substances does not changed. So researchers may look forward in further purification of the extract and then an effective drug loading to get an equivalent potent action from the same quantity of a standard antioxidant.