Plants are utilized as therapeutic agents since time immemorial in both organized (Ayurveda, Unani) and unorganized (folk, tribal, native) form. The ethanolic fruit extract of Cucumis trigonus Roxb of family Cucurbitaceae was used to treat the urolithiasis induced by ethylene glycol. On this course, the extract also repairs the changes that happened in the mineral constituents like calcium, magnesium, phosphorus and oxalate in serum and urine of the urolithiatic rats. The ethanolic fruit extract (150 mg / kg b.w.) elevated the levels of reduced mineral parameters like calcium, magnesium and phosphorus and reduced the level of oxalate in serum and reduced the levels of calcium, phosphorus and oxalate and elevated the level of magnesium in urine significantly (p