Oral drug delivery is the most widely used and acceptable drug delivery amongst the other delivery. The orally disintegrating tablets are available in the market providing one to two minute of disintegration time. Among fast dissolving drug delivery systems, oral strip (OST) drug delivery system is an alternative to tablets, capsules, and syrups for paediatric and geriatric patients who experience in difficulties of swallowing traditional oral solid dosage forms. This technology has been used for local action, rapid release of products and for direct systemic circulation in the oral cavity to release drug in rapid fashion. And also this delivery protect drug from first pass metabolism and improve the dissolution. The main attention towards OST review article is providing knowledge of materials used in OST, critical manufacturing aspects, applications, commercial technologies.