Clerodendron serratum spreng is very much effective in preventing Dalton’s Ascetic Lymphoma cell in mice which was confirmed by evaluating the hematological parameters. Peritoneal cell count, solid tumors volume, body weight and histopathological studies. This holds great promise for future research in human beings. The anticancer properties of Clerodendron serratum spreng will provide useful information in the possible application in cancer prevention and cancer therapy. The treatment with ethanolic and aqueous extracts of Clerodendron serratum spreng significantly altered all the parameters, near to normal. Maximum alteration of parameters occurred in the group treated with the aqueous extract at the dose of 300 mg/kg/day.