Transdermal films of Diclofenac Sodium were formulated by using Hyptis suaveolens seeds mucilage as film forming agent in various concentration. According to the research articles and mucilage can be used as film forming agent. Hyptis suaveolens seeds mucilage is naturally occurring polymer containing polysaccharide which cannot be used as film forming agent before. There are tremendous researches on natural polymers in today’s world because of various advantages of natural polymer over synthetic. Therefore we can take it for further examination as film forming agent and its evaluation. Drug polymer interactions determine by using FTIR and DSC. The medicated films were evaluated for physicochemical properties and also medicated films were evaluated for area variation, drug content and percent cumulative drug release. In vitro drug release study through cellophane membrane indicates that hydrophilic polymer showed higher release. The release rate found to follow first order rate kinetic. The prepared patches will evaluated for thickness, folding endurance, tensile strength, drug contain uniformity, in-vitro permeation study. In vitro drug release study was performed by using artificial membrane.