Hyperglycemia can be a serious problem if untreated in time. Chronic hyperglycemia that persists even in fasting states is most commonly caused by diabetes melitus, and in fact chronic hyperglycemia is the defining characteristic of the disease. Diabetes mellitus is the only non-infectious disease designated as an epidemic by the world health organization. This could have long lasting adverse effects on nation´s health and economic, especially for developing countries. the international diabetes federation(IDF) estimates the total number of people in India with diabetes to be around 50.8 million in 2010, rising to 87.0 million by 2030. The primary goal in the management of diabetes mellitus is the maintenance of blood glucose level.  Therefore, there is an urgent need to develop novel therapeutic agents without the development and progression of complications or compromising on safety. The present review provides an approach for the safe and effective treatment of diabetes melitus.