In present study, a novel series of 6-bromo-2,7,8-trichloro-3-(3’-phenyl-4’,5’-dihydro-1H-pyrazol-5’-yl)quinoline(a-i). These novel synthesized entities were elicited by IR, 1H NMR, 13C NMR, C,H,N Analyzer and mass spectra. The entities produced in laboratory were screened with strains of bacteria and fungi like Staphylococcus aureus, Bacillus Megaterium, Proteus vulgaris, Escherichia coli, and Aspergillus niger respectively. Out of nine different entities synthesized five derivatives showed excellent antibacterial activity and rest of them showed moderate antimicrobial activity.