Anti-asthmatic activity of the alcoholic extract of Physalis angulata roots in ovalbumin induced experimental mice model. The roots were extracted with ethanol and the anti-asthmatic activity of the extract in ovalbumin-induced asthma in albino mice was evaluated. The parameters assessed were assessment of lung inflammation, OVA-specific immunoglobulin E titre by ELISA and histopathology of lung. The extract (100 and 200 mg/kg I.p) inhibited ovalbumin induced asthma by decreasing releasing of inflammatory mediators. Physalis angulata roots extract has potent anti-asthmatic activity. Its anti-asthmatic property probably acts via a reduction in inflammatory mediator’s release. The present study indicates that Physalis angulata has significant anti-asthmatic property.