New ion – associate complexes of the two gliptin drugs, vildagliptin and saxagliptin were precipitated with tetraiodometrcurate and ammonium reineckate and the excess unreacted metal complex was determined. New methods were given for the determination of these drugs in pure solutions, pharmaceutical formulations and urine samples using atomic absorption and atomic emission spectrometry. The drugs can be determined by the afford methods  in the ranges 0.68 – 74.69 and 0.70 – 77.42 μg / ml for vildagliptin and saxagliptin, respectively.