The microspheres are also called as micro-particles. To overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug they are designed. At the target tissue the drug should deliver in an optimal amount in the right period of time with the minimum side effect & maximum therapeutic effect, to get the desired effect. The microspheres received much attention not only for the prolonged release but also for targeting of the anticancer drugs to the tumour. The microsphere are spherical microparticles & are used where predictable & consistent particle surface area is important. . The microspheres has the drug located centrally within the particle where it is encased within the unique polymeric membrane. This review focuses on types, materials used, different methods of preparation, evaluation & applications of microspheres.