Rabies is a fatal viral zoonotic disease transmitted to humans through bites or scratches by infected domestic and wild  animals. It  is present in  all continents except  Antarctica and mostly endemic in Asian and African countries. In countries like India and China, dogs are one  of  the  major  reservoir  hosts  for  the  transmission  of  this  disease.  This  disease  is unpreventable  with the  lack of  awareness and proper  treatment  measures are not being followed up  with patients who  reside particularly in  rural areas. It is because  most Post Exposure Prophylaxis (PEP) needs are borne by patients  who can  least afford  to yield. Rabies vaccines have come a long way following the development of a vaccine by Louis Pasteur in 1885 which is  still being  used to control  rabies in animals  and humans.