In this study crude leaf extract of Parthenium, were tested for their larvicidal activity. The different solvents were used namely ethanol, methanol, water (aqueous) for the preparation of crude extracts from the plant leaves. The larval mortality after 24 hours of exposure were observed separately at concentration like 0.2mg, 0.4mg and 1m extract. The different concentration solvent extract of the plants showed good larvicidal activity. The highest potency was recorded by methanol extract of Parthenium. From These results it was observed that the leaf extract of parthenium contain toxic compounds to mosquito larvae and therefore suggest that parthenium extract has potential in the control of the malaria control and prevention of larvae for social health and can be developed and used.