Comparative antidiabetic potentials study of the effect of ethanolic and aqueous extract of readymade nutmeg with glibenclamide was carried out on thirty (30) male and female albino rats and thirty (30) male and female albino mice for the period of 7, 14, 21 and 35 days. The animals were given low, medium and high doses of extract and 5mg/kg per body weight of glibenclamide for the period. The group administered with high dose of extract of nutmeg had significant  reduction in blood glucose level than (p