Acquired Immunodeficiency Syndrome (AIDS) is a clinical infirmity that is a result of infection with Human immunodeficiency virus (HIV), which causes intense immunosuppression. Many compounds of plant origin that inhibit HIV during various stages of cycle theses include several alkaloids, Carbohydrates, Xanthenes and tannins. These compounds have the capability to come up as a medication for therapy of HIV infection. Herbal medication provides rational means for the therapy of Aids, the Herbal drugs which are utilized in Nut, Turmeric, Asoka, Sarpagandha, Cotton Seed, Arjuna. So, the focus of this review article is to pinpoint possessing activity against HIV objective of providing an effective approach for prevention of transmission and therapy of these diseases.