Argyria defined the different cosmetic alteration that can develop if enough silver particle deposit in specific tissue, typically in the skin its ranging localized dark-blue mucules to generalized slate gray/bluish tinge systemic absorption. In these work aim is fully review the state of the art regarding etiology, epidermiology, pathophysiology, histology, sign and symptoms, evaluation, treatment and differential diagnosis of argyria. Argyria has been diagnosed in wide range ages and sexes and varied ethicities.