Barriers to an early antimicrobial conversion from parenteral to non-parenteral routes are an important problem in the current scenario. Barriers such as a lack of appropriate guidelines for conversion therapies, a lack of culture sensitivity tests for selecting sensitive antibiotics, a lack of supervision by healthcare professionals on converted regimens, a lack of awareness among the patient population about the effectiveness of conversion therapy, and a lack of oral variant antibiotics for its intravenous agents on the market must be identified and resolved. The majority of barriers could be resolved by means of educational, interventional, and structural organizational changes. This may reduce the duration of parenteral antibiotic therapy and the consequent length of stay in hospital. This article review focuses on barriers involved in intravenous to oral antimicrobial conversion therapy and their rectifiable methods. Antibiotics are the most powerful weapons for infectious diseases and could be used in the most appropriate manner by resolving the barriers involved in such conversion therapies and improving the quality of life.