The Piper chaba ethanolic extract showed protection against characteristic lesions produced by ulcer due to Indomethacin administration. This gastroprotective effect of Piper chaba ethanolic extract may be due to both reductions in gastric acid secretion and gastric cytoprotection which may further contribute in the treatment of peptic ulcers. Indomethacin produces necrotic lesions in the gastric mucosa by reducing the secretion of bicarbonate and production of mucus, increasing vascular permeability and decreasing non-protein sulfhydryl groups of gastric mucosa. Indomethacin rapidly penetrates the gastric mucosa apparently causing cell and plasma membrane damage leading to increased intracellular membrane permeability to sodium and water and thus causing gastric mucosa damage. Suppression of prostaglandins synthesis by ethanol results in increase susceptibility of the stomach to mucosal injury and gastro duodenal ulceration. The Piper chaba ethanolic extract significantly reduced ulcer index. The Piper chaba ethanolic extract showed protection against characteristic lesions produced by ulcer due to Indomethacin administration. This gastroprotective effect of Piper chaba ethanolic extract may be due to both reductions in gastric acid secretion and gastric cytoprotection which may further contribute in the treatment of peptic ulcers.