Rivea hypocrateriformis (Desr.) Choisy, a woody climbing shrub belonging to the Convolvulaceae family, is widely distributed across India, Nepal, Sri Lanka, Pakistan, Bangladesh, Myanmar, and Thailand. In traditional medicine, various parts of this plant, including its bark, stems, and leaves, have been employed to address a range of health concerns, such as malaria, cancer, mental disorders, and pain relief. This study aimed to explore the qualitative and quantitative phytochemical analysis of R. hypocrateriformis leaves. Qualitative phytochemical analysis identified the presence of alkaloids, carbohydrates, flavonoids, glycosides, phenolic compounds, and tannins while the quantitative phytochemical analysis showed that ethanolic extract is richest in phenolic and flavovonids content. This study on R. hypocrateriformis leaves serves as a crucial diagnostic tool for species identification, and the development of quality parameters. The data obtained in this study may be regarded as a reference for future research endeavors.