Inflammation plays key role in various diseases such as asthma, atherosclerosis and rheumatoid arthritis. Inflammation is defined as the local response of living mammalian tissues to tissue injury due to any agent. It is a body defense reaction in order to eliminate or limit the spread of injurious agent as well as to remove the consequent necrosed cells and tissues. Leucas aspera is a used orally as stimulant, anthelmintic, laxative, diaphoretic, for the treatment of headache, asthma, and bronchitis. The decoction of roots, stem of Leucas aspera is used orally for high fevers, for influenza, and for malarial fevers. Cassia tora commonly is used as tonic, carminative and stimulant. According to Ayurveda the leaves and seeds are acrid, laxative, antiperiodic, anthelmintic, ophthalmic, liver tonic, cardiotonic and expectorant. This study was aimed to evaluation of anti-inflammatory activity of the roots of Leucas aspera and Cassia tora.