<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Article Tag Suite 1.1//EN"
  "https://jats.nlm.nih.gov/publishing/1.1/JATS-journalpublishing1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink"
         xmlns:mml="http://www.w3.org/1998/Math/MathML"
         article-type="research-article"
         xml:lang="en">
  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>American Journal of PharmTech Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AJPTR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2249-3387</issn>
      <publisher>
        <publisher-name>undefined</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">DOI 10.5281/zenodo.15583299</article-id>
      <article-id pub-id-type="publisher-id">AJPTR152009</article-id>
      <title-group>
        <article-title>Assessing Risk Factors in Patients With Pituitary Adenoma : A Systematic Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Jaybhaye</surname>
            <given-names>Dipak R</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Shinde</surname>
            <given-names>Priya S</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Pisal</surname>
            <given-names>Yash</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>More</surname>
            <given-names>Shruti</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Veer</surname>
            <given-names>Sanika</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="epub" iso-8601-date="2025-04-01">
        <month>04</month>
        <day>01</day>
        <year>2025</year>
      </pub-date>
      <volume>15</volume>
      <issue>2</issue>
      <abstract>
        <p>This study, Identifying Risk Factors in Pituitary Adenoma Patients, examines how pituitary adenomas disrupt the hypothalamic-pituitary-gonadal (HPG) axis, leading to menstrual irregularities such as amenorrhea, oligomenorrhea, and polymenorrhea. Key risk factors include prolactin levels, tumor size, adenoma type, and patient demographics. Prolactinomas are strongly linked to menstrual disturbances due to prolactin-induced suppression of GnRH, LH, and FSH. Macroadenomas worsen dysfunction by compressing adjacent structures, while non-functioning adenomas contribute indirectly through metabolic alterations. Dopamine agonists (cabergoline, bromocriptine) are first-line treatments for prolactinomas, while surgical intervention is preferred for macroadenomas. Persistent hormonal imbalances may require long-term monitoring and personalized management. Early diagnosis and targeted treatment are essential for optimizing reproductive health in affected patients.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Prolactin Levels</kwd>
        <kwd>Tumor Size</kwd>
        <kwd>Adenoma Type</kwd>
        <kwd>Hormonal Imbalances</kwd>
        <kwd>Patient Age</kwd>
        <kwd>Response to Treatment</kwd>
        <kwd>Tumor Duration</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <!-- Full article body not available in metadata-only JATS export. See PDF/HTML galley. -->
  </body>
  <back/>
</article>
