The main aim of present study is to formulation & optimize Gliclazide alginate microspheres by plackett burman’s factorial design. Which offers a flexible and easily controllable process for the manipulating the characteristics of the beads which is important in controlling the release rate and consequently the absorption of Gliclazide from the GIT, variation in polymer, concentration, time of gelation in the external phase were examined systemically for their effects on rate release and entrapment efficiency by Plackett Burman’s factorial design. The swelling behavior strongly depends on the polymer concentration. The result of the study will depends on the release profile of the drug from the formulation. The formulations follows zero order kinetics for the drug release. The in vitro release study indicates that the swelling is the main parameter in controlling the release rate from microcapsules.