Breast and cervical cancers remain one of those significant global health challenges and are among the leading causes of mortality in women. Chalcone derivatives have attracted considerable attention owing to their diverse pharmacological properties, particularly their potential anticancer activity. In addition, the cytotoxicity evaluation against normal human cells indicated relatively low toxicity, highlighting the therapeutic potential and selectivity of these compounds. Collectively, in previous study [1] the results suggest that Chalcone represent promising lead candidates for the development of anticancer agents, while the MAOS methodology offers an efficient, high-yielding, and environmentally benign synthetic strategy consistent with green chemistry principles.