Erectile dysfunction is the sexual dysfunction characterized by inability to maintain an erection of penis during sexual performance. Oral phosphodiesterase type 5 inhibitors drugs are successful for treatment of impotence such as sildenafil, vardenafil, tadalafil, alprostadil and avanafil. Clinical trials reveals that avanafil have faster onset of action as well as higher specificity for phosphodiesterase type 5 inhibitors with fewer side effects in comparision of other oral phosphodiesterase type 5 inhibitors drugs. In case of analytical method only LC-MS/MS method has been done. There may be chances of analytical study of avanafil will be done in future by using various spectroscopy method.