Abuse, misuse and diversion of drug substance are one of the most growing problems of United States and all over the world. The most critical challenge in combating the problem of drug abuse is to balance the control of prescription drugs along with continued access for legitimate use. To overcome the increasing problem of drug abuse, development of abuse deterrent formulation can prove an effective tool. This review provides an overview of abuse, modes of abuse, drugs with abuse potential, and different approaches for development of abuse deterrent formulations. Due to high mortality and morbidity, Opioids are the drug of choice for development abuse deterrent formulation. Hence draft guidance of US F.D.A. (US Food and Drug administration) for evaluation and labeling of abuse deterrent Opioid formulations are also under the scope of this review.