The hepatoprotective activity of a Boerrhavia diffusa of 50 % ethanolic extract  was studied using Swiss albino rats. The animals received a single intraperitoneal injection of N-nitrosodiethylamine 200mg/kg body wt followed by subcutaneous injection of CCl4 in a dose of 3 ml/kg body wt. The administration of  Boerrhavia diffusa extracts and cisplatin decreased the liver weight and average liver weight, which shows the rehabilitating capability of extracts in respect with anticancer potency in comparison with the very much effective in preventing NDEA-induced multistage hepatocarcinogenesis possibly through antioxidant and  antigenotoxic nature, which was confirmed by various liver injury and biochemical tumour markers enzymes and molecular events. Boerrhavia diffusa extract dose dependently and significantly the increase in serum hepatic enzyme levels after NDEA& CCl4 treatment compared to the toxin control group. The results of this study confirmed the antioxidant and hepatoprotective activity of the Boerrhavia diffusa extract against carbon tetrachloride& N-nitrosodiethylamine induced hepatotoxicity in Swiss albino rats.