Immunomodulators are natural or synthetic substances that help in regulation or normalize or modify the immunity of an individual to favor a particular immunological response. Immunomodulator corrects immune systems that are out of balance. Natural immunomodulators are less potent than prescription immunomodulators. Synthetic immunomodulators medications, work by suppressing immune system and decreasing inflammation in the digestive tract in people with inflammatory bowel disease, ulcerative colitis etc. The benefits of immunomodulators are from their ability to stimulate natural and adaptive defense mechanisms, such as cytokines, which enables the body to help itself. Two types of immunomodulators: Immunosuppressants; agents which suppress immune system and used for the control of pathological immune response in autoimmune disease and Immunostimulants; agents which used to enhance body's resistance against infections. A large number of disorders such as immunodeficiency state, autoimmune disease, cancer and viral infection can be treated with immunostimulants drugs.