A series of [6-(p-substituted aminophenyl)-4-(p-substituted phenyl)—6H-1,3 thiazin-yl]-acetamides were synthesized via Claisen-Schmidt condensation. The titled compounds were characterized by IR, NMR analysis. The synthesized compounds were screened for their antibacterial and antifungal activity disc diffusion method. Among the synthesized compounds, T-2 was found to have a strong antibacterial and antifungal activity. Compounds T-1, T-3, T-4 and T-5 were found to have promising antimicrobial activity.