Sublingual administration of the drug is known as placement of the drug under the tongue and drug reaches directly in to the blood stream. The concept of formulating sublingual tablets of Prochlorperazine maleate offers suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic. Bitter taste of Prochlorperazine maleate was masked by inclusion complex with β-cyclodextrin and then sublingual tablets were prepared using various natural superdisintegrants such as hibiscus-rosa and fenugreek and synthetic superdisintegrants like Indion 414 and kyron T-314 in different concentrations by direct compression method. Prepared tablets were subjected to different evaluation parameters such as hardness, thickness, friability, weight variation, drug content uniformity, in-vitro disintegration time, water absorption ratio, wetting time, in vitro dissolution studies and stability studies are carried out by using best formulation. Overall, formulation F3 (10 mg of Indion 414) and F9 (10 mg of Hibiscus-rosa) based on disintegration time, wetting time and drug release were found to be an excellent formulations. Hence It was found that there was no significant difference between F3 and F9, which shows that natural superdisintegrants (10 mg of Hibiscus rosa) is as good as synthetic superdisintegrants (10 mg of Indion 414). Hence it proves that synthetic disintegrant can be replaced by natural disintegrants due to easy availability and compatibility.